NEJM TTM2: hypothermia (33C for 28 hrs then avoid >37.8C to 72 hrs) vs normothermia ( <37.8C), after OHCA + coma = no difference death and poor functional outcome at 6 months. In general TTM1 and 2 report no difference between 33, 36, and 37.8C.
Saturday, May 29, 2021 - 17:55
JAMA COBI RCT continuous infusion 20% hypertonic saline vs standard care for minimum 48 hours in moderate to severe TBI = no difference neurological outcome 6 months. Intervention associated lower risk intracranial hypertension for 1st 2-days, followed by rebound ICH, apparent after cessation of therapy.
NEJM CONFIRM terlipressin with albumin more effective than albumin alone at reversing hepatorenal syndrome in adults with cirrhosis and HRS-1. Interesting cautionary discussion about terlipressin association with more serious adverse events, particularly respiratory failure..